Imaging classification and analysis of the diagnosis and treatment of infected pancreatic necrosis:a report of 126 cases / 中华外科杂志

Objective: To explore the clinical characteristics of various types of infected pancreatic necrosis(IPN) and the prognosis of different treatment methods in the imaging classification of IPN proposed. Methods: The clinical data of 126 patients with IPN admitted to the Department of Pancreatic and Biliary Surgery, the First Affiliated Hospital of Harbin Medical University from December 2018 to December 2021 were analyzed retrospectively. There were 70 males(55.6%) and 56 females(44.4%), with age(M(IQR)) of 44(17)years (range: 12 to 87 years). There were 67 cases(53.2%) of severe acute pancreatitis and 59 cases (46.8%) of moderately severe acute pancreatitis. All cases were based on the diagnostic criteria of IPN. All cases were divided into Type Ⅰ(central IPN)(n=21), Type Ⅱ(peripheral IPN)(n=23), Type Ⅲ(mixed IPN)(n=74) and Type Ⅳ(isolated IPN)(n=8) according to the different sites of infection and necrosis on CT.According to different treatment strategies,they were divided into Step-up group(n=109) and Step-jump group(n=17). The clinical indicators and prognosis of each group were observed and analyzed by ANOVA,t-test,χ2 test or Fisher exact test,respectively. Results: There was no significant difference in mortality, complication rate and complication grade in each type of IPN(all P>0.05). Compared with other types of patients, the length of stay (69(40)days vs. 19(19)days) and hospitalization expenses(323 000(419 000)yuan vs. 60 000(78 000)yuan) were significantly increased in Type Ⅳ IPN(Z=-4.041, -3.972; both P<0.01). The incidence of postoperative residual infection of Type Ⅳ IPN was significantly higher than that of other types (χ2=16.350,P<0.01). There was no significant difference in the mortality of patients with different types of IPN between different treatment groups. The length of stay and hospitalization expenses of patients in the Step-up group were significantly less than those in the Step-jump group(19(20)days vs. 33(35)days, Z=-2.052, P=0.040;59 000(80 000)yuan vs. 122 000(109 000)yuan,Z=-2.317,P=0.020). Among the patients in Type Ⅳ IPN, the hospitalization expenses of Step-up group was significantly higher than that of Step-jump group(330 000(578 000)yuan vs. 141 000 yuan,Z=-2.000,P=0.046). The incidence of postoperative residual infection of Step-up group(17.4%(19/109)) was significantly lower than that of Step-jump group(10/17)(χ2=11.980, P=0.001). Conclusions: Type Ⅳ IPN is more serious than the other three types. It causes longer length of stay and more hospitalization expenses. The step-up approach is safe and effective in the treatment of IPN. However, for infected lesions which are deep in place,difficult to reach by conventional drainage methods, or mainly exhibit "dry necrosis", choosing the step-jump approach is a more positive choice.

Basic principles,methods and evaluation of minimally invasive treatment for infected pancreatic necrosis / 中华外科杂志

Infected pancreatic necrosis(IPN) is the main surgical indication of acute pancreatitis. Minimally invasive debridement has become the mainstream surgical strategy of IPN,and it is only preserved for IPN patients who are not response for adequate non-surgical treatment. Transluminal or retroperitoneal drainage is preferred,and appropriate debridement can be performed. At present,it is reported that video assisted transluminal,trans-abdominal and retroperitoneal approaches can effectively control IPN infection. However,in terms of reducing pancreatic leakage and other complications,surgical and endoscopic transgastric debridement may be the future direction in the treatment of IPN.

Infecciones intraabdominales: Puesta al día y recomendaciones de la sociedad Argentina de infectología / Intra-abdominal infections. Update and recommendations

Las infecciones intraabdominales constituyen un grupo de procesos intra y retroperitoneales, desde cuadros localizados hasta infecciones complicadas, sepsis o shock séptico, con elevada mortalidad. Representan la tercera causa de sepsis y la segunda causa de muerte en unidades de terapia intensiva. El tratamiento antimicrobiano debe iniciarse lo antes posible, especialmente en pacientes en estado crítico, pero también es fundamental el procedimiento de control del foco. Dada la importancia del tema, representantes de la Sociedad Argentina de Infectología junto con especialistas en Terapia Intensiva elaboraron estas recomendaciones sobre su diagnóstico, tratamiento y prevención. A tal fin, revisaron y analizaron la bibliografía publicada sobre el tema en los últimos 10 años, además de la opinión de expertos y datos locales. El documento ofrece herramientas básicas de diagnóstico basadas en criterios clínicos y microbiológicos, orientación sobre esquemas antibióticos empíricos y dirigidos según foco de origen, lugar de adquisición (comunidad o asociadas al cuidado de la salud) y gravedad de la infección, duración del tratamiento, importancia del control del foco y medidas preventivas para reducir el riesgo de infección del sitio quirúrgico. Asimismo, se presenta un algoritmo sencillo de diagnóstico y tratamiento para uso en la actividad asistencial. El trabajo pone en evidencia la preocupación por el tratamiento de las infecciones intraabdominales, estableciendo pautas locales para mejorar su diagnóstico, tratamiento y prevención, con el objeto de disminuir morbimortalidad, días de internación, costos y resistencia antimicrobiana.

Intra-abdominal infections represent a group of intra and retroperitoneal processes, ranging from localized infections to complicated ones, sepsis and septic shock, associated with a significant mortality rate. They are the third most commonly identified cause of sepsis and the second cause of death in the intensive care unit. Although antimicrobial therapy must be started as soon as possible, especially in critically ill patients, the source control procedure is highly relevant. On account of the importance of this subject, members of the Argentine Society of Infectious Diseases (SADI) and intensive care specialists joined to develop recommendations on diagnosis, treatment, and prevention of intra-abdominal infections. The literature published within the last 10 years was reviewed and analyzed, in addition of expert opinions and local data. This statement provides a basic tool for diagnosis based on clinical and microbiological criteria, orientation on empirical antimicrobial therapy schemes according to source, acquisition place (community or healthcare associated infections), infection severity, treatment duration, importance of source control, and preventive measures aimed to reduce surgical site infection risk. Likewise, it provides a simple algorithm for diagnosis and treatment for use in clinical practice. The work reveals the concern about the management of intra-abdominal infections, establishing local guidelines to optimize diagnosis, treatment and prevention, with the aim of reducing morbidity, mortality, length of stay, costs and antimicrobial resistance.

Pileflebite: relato de caso / Pylephlebitis: case report

A Pileflebite é uma rara e grave complicação de diversas infecções intra-abdominais e pélvicas. Inicia-se através de uma tromboflebite de pequenos vasos que drenam uma área infectada e tem, como principais manifestações, a dor abdominal e a febre. É descrito caso de trombose séptica de veia porta em uma paciente do sexo feminino, 70 anos, hipertensa, obesa, portadora de neoplasia maligna de uretra e tabagista, que apresentou episódio de diverticulite aguda complicada com pileflebite. Tratamento realizado com antibioticoterapia e anticoagulação.

The pylephlebitis is a rare and serious complication of various abdominal and pelvic infections. It begins with thrombophlebitis of small vessels that drain an infected area, and has abdominal pain and fever as main manifestations. It describe the case of portal vein septic thrombosis in a female patient, 70 years, smoker, suffering from systemic hypertension, obesity and malignant neoplasm of urethra, who had an episode of acute diverticulitis complicated by pylephlebitis. Treatment instituted with antibiotics and anticoagulation.

Heart and systemic effects of statin pretreatment in a rat model of abdominal sepsis. Assessment by Tc99m-sestamibi biodistribition

PURPOSE: To evaluate the heart and the Tc-99m-sestamibi biodistribution after statin pretreatment in a rat model of abdominal sepsis. METHODS: Twenty-four Wistar rats were randomly distributed into four groups (n=6 per group): 1) sepsis with simvastatin treatment, 2) sepsis with vehicle, 3) sham control with simvastatin and 4) sham control with vehicle. 24 hours after cecal ligation and puncture rats received 1.0MBq of Tc-99m-sestamibi i.v. 30min after, animals were euthanized for ex-vivo tissue counting and myocardium histological analysis. RESULTS: Myocardial histologic alterations were not detected 24 hours post-sepsis. There was significantly increased cardiac Tc-99m-sestamibi activity in the sepsis group with simvastatin treatment (1.9±0.3%ID/g, p<0.001) in comparison to the sepsis group+vehicle (1.0±0.2%ID/g), control sham group+ simvastatin (1.2±0.3%ID/g) and control sham group (1.3±0.2%ID/g). Significant Tc-99m-sestamibi activity in liver, kidney and lungs was also detected in the sepsis group treated with simvastatinin comparison to the other groups. CONCLUSIONS: Statin treatment altered the biodistribution of Tc-99m-sestamibi with increased cardiac and solid organ activity in rats with abdominal sepsis, while no impact on controls. Increased myocardial tracer activity may be a result of a possible protection effect due to increased tissue perfusion mediated by statins. .

Sepsis intraabdominal diseminada: análisis de 119 operados en 10 años / Spreading intra-abdominal sepsis: analysis of 110 patients operated on during 10 years

INTRODUCCIÓN. La atención a los pacientes con de sepsis intraabdominal diseminada continúa presentado variantes de conducta. A pesar de los adelantos terapéuticos, los índices de mortalidad continúan siendo elevados y oscilan entre el 30 y el 60 por ciento. Dicha oscilación está influenciada, en ocasiones, por la selección de la muestra. El objetivo principal del presente estudio fue conocer el comportamiento de la sepsis intraabdominal diseminada entre los años l995 y 2005, en nuestra institución. MÉTODOS. Se realizó un estudio retrospectivo y prospectivo de los pacientes con sepsis intraabdominal diseminada, operados entre l995 y 2005 en el Servicio de Cirugía General del Hospital Docente Clinicoquirúrgico Joaquín Albarrán. Fueron revisados 119 expedientes clínicos y 49 protocolos de necropsia. Se estudiaron grupos etarios, patologías más frecuentes, síntomas y signos, efectividad en el diagnóstico, métodos de tratamientos, complicaciones, gérmenes causales y mortalidad. RESULTADOS. Hubo 49 fallecidos (41,1 por ciento) y se constató un incremento del 3 por ciento de la mortalidad en comparación con el año anterior, debido fundamentalmente al aumento del número de dehiscencias de suturas intestinales, ocurridas en el 22,5 por ciento de los fallecidos por falta de una decisión quirúrgica precoz. La mayoría de estos pacientes tenían enfermedades oncoproliferativas. El método de tratamiento local más empleado fue el cerrado (72 pacientes; 60,5 por ciento). En general hubo un cumplimento adecuado del algoritmo de trabajo utilizado en el Servicio(AU)

INTRODUCTION: Care of patients presenting with spreading intra-abdominal sepsis continues presenting behavior variations. Despite therapeutical advances, mortality rates are still high, and fluctuate between 30 percent and 60 percent. Sometimes, such fluctuation is influenced by sample selection. The main objective of present paper was to know the behavior of spreading intra-abdominal sepsis between 1995 and 2005 in our institution. METHODS: Authors made a retrospective and prospective study of patients presenting with spreading intra-abdominal sepsis, operated on between 1995 and 2005 in General Surgery Service of Joaquín Abarrán Clinical Surgical Teaching Hospital. A total of 119 clinical records and 49 necropsy protocols were reviewed. Age groups, more frequent pathologies, symptoms and sings, diagnosis effectiveness, treatment methods, complications, causal germs, and mortality were studied. RESULTS: There were 49 deceased (41, 1 percent) and a mortality increment of 3 percent was confirmed, compared with past year, basically due to raise in number of intestinal suture dehiscences, occurred in 22,5 percent of deceased by a lack of early surgical decision. Most of these patients presented with onco-proliferative diseases. The more used local treatment was the closed one (72 patients; 60, 5 percent). In general, there was an appropriate fulfillment of work algorithm used in the service(AU)

La experiencia clínica con tigeciclina: Una breve revisión / Clinical experience with tygecicline: A brief review

The available clinical experience with tigecycline is analyzed under the perspective of a systematic review of the hterature, related to the already approved indications reported in the recent hterature. The safety profile is checked in the above mentioned clinical trials. The available information allows supporting tigecycline efficiency in the managing of complicated skin and soft tissues infections, complicated intrabdominales infections and in community acquired pneumonias.

Se analiza, bajo la perspectiva de una revisión sistemática de la literatura médica, la experiencia clínica con tigeciclina, en las indicaciones ya aprobadas por las entidades reguladoras reportadas en la literatura reciente. Se revisa el perfil de seguridad y tolerabilidad en dichos ensayos clínicos. La información disponible permite avalar su eficacia en el manejo de infecciones de piel y tejidos blandos complicadas, infecciones intra-abdominales complicadas y neumonías adquiridas en la comunidad.